Amy (Danielle Harris) prepares to leave her job at the city morgue while Seth (Kaj-Erik Eriksen) and their boss Holden (Michael Eklund) work the graveyard shift. As Amy is leaving to meet friends at a bar for her birthday, Holden receives news that a number of bodies are being delivered, the victims of a mass murder committed by Jacob Goodnight (Kane) at the Blackwell Hotel. Amy decides to cancel her plans and help her colleagues with the deliveries. Amy and Seth process the corpses, including that of Goodnight. As Amy leaves Seth to finish the work, she is surprised to find Holden has allowed her friends Tamara (Katharine Isabelle), Kayla (Chelan Simmons), Carter (Lee Majdoub) and her brother Will (Greyston Holt) to throw a birthday party in the morgue. During the party, Will warns Seth to stay away from Amy, believing she deserves better than him, causing Seth to leave the party and return to work. Will tells Amy of his disapproval of her dropping out of Med School to work in the morgue, angering Amy, who also leaves the party.

Tamara, who is fascinated by death and serial killers, leaves the party with Carter to go look at Jacob’s body. The experience of being in a room with the body of a real murderer arouses her and she and Carter begin to have sex. Jacob suddenly awakens, and kills Carter while Tamara escapes. Jacob searches the room, outfitting himself with a burn victim mask and several surgical tools before cutting the building’s electricity.

Hearing Tamara’s screams, the rest of the partygoers attempt to find her; Holden, away from the rest, is captured and mortally wounded by Jacob.